On the TRAIL of therapeutic antibody treatments

Monoclonal antibodies are important research tools in the fight against cancer.But they have also proven to be powerful therapeutic tools in their own right,owing to their ability to target specific proteins expressed by tumour cells. Recently,researchers at the Wistar Institute used TRAIL antibody products to develop a new combination therapy for malignant brain tumors.

Notch signalling antibodies and the jagged edge of cancer research

An extensive antibody catalog exists for the Notch signaling pathway.Notch proteins play an essential role in embryonic development and cell-signaling,with antibody studies showing them to be critical to apoptosis,vasculogenesis, hematopoiesis,myogenesis,morphogenesis and T-cell development.The Notch pathway has also been implicated in various types of cancer.