Articles from August 2011

How the HIF-1 beta antibody aids vascular research

The Hypoxia Inducible Factors are a family of dimeric transcriptional regulators which play an important role in oxidative homeostasis during hypoxic conditions. HIF-1 is composed of alpha and beta subunits, represented by HIF-1 alpha and HIF-1 beta antibody products, both of which are well represented on our antibody database.

HIF-1 is an oxygen-sensitive complex, essential to hypoxic regulation during embryonic vascular development. In humans, the HIF-1 alpha subunit is encoded by the HIF1A gene, whereas the HIF-1 beta subunit is encoded by the ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) gene.

In normoxic conditions, the two subunits are dissociated. HIF-1 beta is located in the nucleus, and HIF-1 alpha in the cytoplasm, where it is rapidly degraded following HIF prolyl-hydroxylase activation. During hypoxia, HIF prolyl-hydroxylase is inhibited, leading to an increase in HIF-1 alpha levels. The alpha subunit then translocates to the nucleus, forming a stable HIF-1 dimer with the HIF-1 beta subunit.

Recent HIF-1 research has indicated HIF-1 stabilisation during hypoxia promotes mRNA stabilization and upregulation of a number of genes, including vascular endothelial growth factor (VEGF). This protein protects the growing embryo during periods of inadequate oxygen delivery, by promoting angiogenesis. However, the HIF-1 complex is also activated during solid tumour formation, owing to increased oxygen demand.

Currently, the HIF-1 beta antibody is one of the products being used to investigate induction of the HIF-1 complex in normoxic cells. It has been shown that chronic inflammatory conditions may cause aberrant functioning of transcription factors such as HIF-1, resulting in altered expression of chemokines, growth factor etc. This in turn may provide ideal “growing conditions” for metastasis and cancer.

 
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The Article is written by novusbio.com providing antibody database and Antibodies Services. Visit http://www.novusbio.com for more information on novusbio.com Products & Services
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Using Your Mobile Phone For International Calls

There was once a time when the very idea of making an international call from your mobile phone was a sure way to hand over a princely sum for only a meagre few minutes of call time. However, mobile phone networks have realised the growing need for cheap international calls since more and more people have opted to use their mobile phones while abroad on holiday or business. Technological innovation involving call routing also advanced making cheap phone calls more readily available to all.

Of course, you can make a direct phone call or text to a mobile that is in another country although this will cost you a lot of money and is by some margin the most expensive option to use.

If you are frequently making international calls or you are abroad yourself, you can pay for a particular phone tariff which allows you to make cheap international calls. This can give you more freedom and peace of mind when making long distance calls from your mobile phone.

Alternatively, you can make use of voice short codes which allow you to dial a 5 digit code in place of the standard geographical area code. This then allows you to be charged at a local rate therefore saving you a great deal of money. The main advantage of this is that it can be charged to your mobile phone operator’s inclusive package meaning that the call could essentially be free with your monthly tariff. Many mobile phone networks now implement this service, including O2, Virgin, Vodafone, Three, Orange and T-Mobile.

One of the greatest advantage to callers is that you are aware of exactly how much you are going to be charged at each point, meaning you can be absolutely sure you are getting cheap phone calls.

 

 

Rig Safety

Being safe at sea isn’t just about training your staff in the right way. Everything from the offshore doors you use through to the processes you undertake within your company are going to make a major difference to how safe both your staff and your costly investments are.

When it comes to items such as watertight doors, it is worth remembering that even if staff are not effected by incoming water, then expensive equipment or resources could well be. It is therefore vital to ensure that all areas of a rig have the right watertight doors and that they are not simply restricted to those areas that house personnel.

The sea is one of the most amazing, fascinating, but also temperamental aspects in all of nature. It offers a great deal for us in terms of potential and in terms of scope, but it also poses many dangers too. Once you have taken the risk of fire, flood and weather damage into account and bought your offshore doors accordingly, it is wise to place a great amount of focus on your staff. Not only do you need to ensure that they are up to the task at hand, but you also need to ensure that they are mentally prepared each and every time they are in charge of a certain task.

Keeping up morale at sea is therefore going to be extremely important and things as small as crew accommodation can make the difference between comfortable, rested personnel and those who may well cause accidents. Simply having their own space to blow off steam or have time to themselves can make a great deal of difference and there will need to be the option for a counterbalance between the stresses of the working day and the comfort of private relaxation.

The best safety plan will involve not only the very best rig and the safest doors, but also the safest staff too.

 
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The Article is written by mmlmarine.com providing marine doors and offshore doors Services. Visit http://www.mmlmarine.com for more information on mmlmarine.com Products & Services
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Designer sunglasses without the premium price tag

Designer stuff is what people want. Those world famous and exclusive labels are plastered over everything from clothing through to bags and sunglasses. Shame it’s so incredibly expensive, but that’s what makes it designer in the first place!

Sunglasses are more than just a sensible way of protecting the eyes on a sunny day. There are a fashion statement. People want to look cool and that means having designer shades, not discount sunglasses. No one wants to look cheap or off trend. And they have pay a huge premium to have the latest designer look.

However, it doesn’t have to be like this. It is possible to get cheap designer sunglasses, if shoppers know where to look that is. Forget the high street. The best place to shop for sunglasses is online over at www.ogglemyspecs.com. Shoppers can forget the absurd prices they see on the high street and grab themselves a bargain instead.

When it comes to cheap designer sunglasses, they are all here. All the big brands and names in the world of fashion. This means shoppers can still look good this summer, but without spending a fortune. There’s nothing different or inferior about these discount sunglasses. They are the same styles, just sold at a much better price.

As an online retailer, the Oggle Partnership can offer its customers a much better deal. They source these glasses at ultra competitive rates and thanks to their lean business model, pass these savings on. Making online shopping the smart way to find great value sunglasses, that still cut it in the fashion stakes.

Ordering online is simple, straightforward and secure. There’s no need to pay over the odds for expensive designer sunglasses ever again. Everyone can look great this summer in shades that are great value and sport those all important designer logos.

 
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The Article is written by ogglemyspecs.com providing Discount sunglasses and cheap designer sunglasses Services. Visit http://www.ogglemyspecs.com for more information on ogglemyspecs.com Products & Services
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What To Look For In After The Event Insurance

As with any litigation proceedings the potential consequences for your organisation could be huge. Defence, claims and counterclaims can be damaging, making after the event insurance a vital avenue for many businesses seeking to hedge cost and credibility.

ATE Insurance can significantly reduce the risk of your litigation fees and provide your organisation with some much needed confidence to proceed in your litigation process. This should cover both your own and your opponent’s potential legal costs (otherwise known as adverse costs).

After the event insurance cover should be scalable to stakes meaning for each case you could be talking anywhere in the region of £100,000 to above £20 million. Depending on your situation this should provide you with some manoeuvrability.

You should be wary that ATE insurance can require you to finance the litigation until its conclusion, whether by private means, establishing a funding agreement with a 3rd party or having reached a prior deferral of payment. Possibly the most alluring part of after the event insurance is that no fee is payable before proceedings, and if the case does not result in success for the client, then no fee is payable whatsoever.

Regardless of a company’s financial capability or size, ATE can be used to effectively level the playing field making for fairer legal proceedings. So regardless of the type of litigation in progress, ATE seems a great way to reduce the risk of legal outcome.

When using ATE, you should be wary of the market and the competitiveness that exists therein. Many independent brokers will provide market evidence that their services are the most cost-effective and manageable for your company by themselves presenting you with market research. It might be a good idea to follow through on this research to make sure their claims are trustworthy.

 
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The Article is written by thejudge.co.uk/ providing after the event insurance and ate insurance Services. Visit http://www.thejudge.co.uk/ for more information on thejudge.co.uk/ Products & Services
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Spice up a visit to London with an escort

London is a city of sin and excitement. In a good way of course. The capital plays host to beautiful women from all over the world. When guys are in town there’s never any reason to be alone. A good London escort service can provide a sexy playmate to party with any time.

Every guy has different tastes and turn ons. London 69 Escorts understand this. They keep a selection of the capital’s most desirable girls on their books. Girls who really know how to pleasure a man. Ebony girls, Asian girls, European hotties, South American beauties and local lovelies. They are all available for an unforgettable few hours of fun.

London escorts are some of the world’s best. The girls at London 69 Escorts are chosen for a variety of qualities. Not only are they drop dead gorgeous, but they’re great fun to be with too. The perfect companion in and out of the bedroom. They know just how to put a guy at ease, as well as turn them on of course.

This London escort service is reliable, discreet and professional. Making a booking is simple and straightforward. Just one call is all it takes to set up a mind blowing encounter with premier London escorts. Every guy needs a break once in a while. A chance to indulge themselves with something new and different. Something they’ve always wanted to try. London 69 Escorts help makes those fantasies a reality. This is companionship at its very best. The girls offer a range of specialist services. It’s just a case of asking ahead to see what is possible.

Spending a few hours with one of these escorts is the perfect way to enjoy a trip to London. There’s no need to end up kicking around in a hotel room alone of an evening. Not when there’s some sizzling company to be had.

 
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The Article is written by london69escorts.com providing london escort and London escort service Services. Visit http://www.london69escorts.com for more information on london69escorts.com Products & Services
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Saving Money on Your Phone Bills

There are many ways to cut the amount of money you spend on your phone bills. With our business and personal lives becoming ever more fast-paced, a great many of us are spending more and more time on our phones. However, the advancement in technology doesn’t necessarily mean you have to spend more on your phone bills – instead, it could actually save you money.

When you are at home, using online phone services such as Skype can be hugely beneficial. Many of these are free and you will be able to not only make free calls, but also potentially have free video calls, a far less impersonal source of communication than the phone can be.

Next, try getting rid of the landline. Many people spend huge amounts on a landline they rarely use. Mobile internet or external hubs can be far cheaper than line rental and many will find that mobile phones can offer the majority of the internet access they need. With tablets becoming more and more advanced all the time, these may also very soon replace the need for home broadband via telephone lines.

SIM free phones can also help. Whether you choose a SIM free iPhone or any of the many androids available without ties to a specific network, the ability to use SIM free phones to let you change service provider as and when you want to could well see you saving a great deal of money as you will always be able to ensure you can get the very best deal.

From using a SIM free iPhone to simply negotiating the tariff you have with the network providing your contract, there are many ways to save a great deal of money. You don’t have to use your phone less to cut your costs – you simply need to know the best way to use them.

 
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The Article is written by superetrader.co.uk providing sim free mobiles and sim free android phones Services. Visit http://www.superetrader.co.uk for more information on superetrader.co.uk Products & Services
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Courses That Can Improve Your Career Options

It seems obvious that the better results you get from school, college or university, the better your chances are of getting the right job. And yet, despite the fact that both experience and education are the overriding factors in choosing new employees, people often don’t consider that they can get both hands-on experience and extra qualifications in any number of areas even after you have joined the world of work.

Volunteering or interning is one great way to get the experience you might need to move into certain areas of business that you might wish to pursue. However, finding such internships can often be as hard as finding a specific job itself, and therefore taking courses will often be the best way forward. From taking a simple payroll course to increase your appeal to major companies through to taking full degree courses from home, the potential to improve your career options is endless.

Many companies offer online learning courses, yet these can take many years to complete in some instances. For those who want to fast track their career, taking intensive, short courses will usually be the best approach. In this arena, there will be many courses that can improve your potential, and of course these will vary from person to person depending on the area they wish to get into. However, certain courses can help almost anyone.

An executive PA course, for instance, will not just help those looking to be a Personal Assistant, but the wealth of skills that they offer participants is so vast that it will also offer almost anyone the chance to prove their organisational, management and written skills.

So from payroll courses through to simple typing and computer training, finding companies online who offer a huge number of courses could easily help you find a way to quickly turn your career around and get it heading in the right direction.

 
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The Article is written by holborntraining.co.uk providing payroll course and sage courses Services. Visit http://www.holborntraining.co.uk for more information on holborntraining.co.uk Products & Services
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Benefits of Macs over PCs

Whether it is a first time purchase or a requirement to replace a broken computer, trying to decipher whether to get a Macintosh or PC can be a difficult task. In the same way that a customer would consider the pros and cons of all other electrical and household appliances to ensure they purchased the item they consider to be the most effective, Apple and Windows have been competing for computer prominence since the mid 1980s. While Windows enjoy an overwhelming percentage of market share for operating systems, this should not necessarily lead to the conclusion that PCs are the prime choice for computers and laptops.

Indeed, owning a Macintosh computer offers numerous advantages over a PC which can summarise why companies and schools use Apple in business and education for respective purposes. Macs run upon an operating system titled OS X which offers a more simplistic and user friendly interface than Windows and is considered more efficient. While this remains the main difference, the ability to use any operating system on a Mac computer is a significant advantage. Macs provide the versatility and ability to run OS X and Windows from one computer, but OS X cannot be installed onto a PC unit.

Its compatibility with other brand products is additionally another significant reason why there is an integration of Apple in education and Apple in business. While PCs can occasionally encounter issues when connected to an iPhone, iPad or any other Apple equipment, Mac computers sync perfectly with their fellow creations. Software can be a major factor within the business and education industry which may tip the balance towards Macs as they offer more constructive and reliable full version editions ready for use.

Purchasing a Mac grants support from Apple Support for any technical issues, while there are also several Apple experts who offer expert assistance and advice towards getting the most from Macintosh computer and all other products. Although it is a matter of personal choice, Macs offer several benefits to any industry field.

 
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The Article is written by albion.co.uk providing apple in business and internet for business Services. Visit http://www.albion.co.uk for more information on albion.co.uk Products & Services
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Choosing a Summer House to Suit Any Garden

During the summer months many people enjoy sitting outside in their garden taking in the sunshine and relaxing. However, the British weather is infamous for being unpredictable and sunny days are often rare and sporadic which can sometimes prevent any utilisation of this garden space. Summer houses provide a viable solution to this problem. A summer house provides the perfect shelter from an impromptu shower and also a tranquil area to relax when the sun shines.

Summer houses can be fully enclosed which is perfect for use whatever the weather and, despite their name, even in winter. They can also have open sides more suitable for use during the summer, providing shelter from a sudden burst of rain or an area of cool shade to take respite under away from the sun.  There is also many other different features to choose from. It is worth considering the look and style of the garden itself. Thatched roofs are an alternative option that may work well with a country style home. Some come with additional decking or include tables and seating areas that are built in which saves expenses on extra furniture. With open gazebos a handrail around the side may appeal and for enclosed summerhouses windows and doors can be tailored to personal preference. Many of the structures are supplied in kit form which should appeal to any ‘do it yourself’ enthusiast but instructions are usually simple to follow for the more apprehensive builder.

Summer houses are ideal for socialising and hosting garden parties or even enjoying a family meal outdoors on a balmy summer evening. What better way to entertain your guests than in an idyllic garden setting. They are also practical places to partake in an activity such as painting or reading whilst reaping the benefits of some fresh air.

 
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The Article is written by dunsterhouse.co.uk providing log cabins and climbing frames Services. Visit http://www.dunsterhouse.co.uk for more information on ailguk.com Products & Services
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